BENCE-JONES PROTEINEMIA IN MULTIPLE MYELOMA 1
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چکیده
منابع مشابه
Bence-jones Proteinemia in Multiple Myelomai
The term "Bence-Jones protein" refers to an ill-defined group of proteins having a molecular weight of approximately 37,000 (1), and the characteristic properties of precipitating out of solution when warmed to 45 to 58° C. and of redissolving completely or partially on boiling. This peculiar behavior on heating has long served as a useful test for Bence-Jones proteins in the urine of patients ...
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Bence-Jones proteinuria refers to urinary excretion of monoclonal light chains. It results from exclusive production of one light chain, or the unbalanced synthesis of heavy and light chains, with the latter being in excess. Free Kor A-light chains are therefore excreted alone or in addition to complete immunoglobulin molecules carrying the same light chain type. Free light chains are low molec...
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A 40-year-old man was found to have proteinuria on a routine medical checkup in 1993. Further examination showed an erythrocyte sedimentation rate of 7 mm/h, hemoglobin 15.1 g/dL, white cell count 3,400/mm, platelet count 175,000/mm, IgG 366 mg/dL, IgA 11 mg/dL, IgM 10 mg/dL, blood urea nitrogen 25 mg/dL, and creatinine 1.2 mg/dL. Immunoelectrophoresis revealed Bence Jones protein (к light chai...
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We report our findings of Bence Jones proteins (monoclonal free light chains of immunoglobulins) in concentrated urines of patients with multiple sclerosis, by using agarose electrophoresis and immunofixation. The lack of such findings in urines from healthy subjects and patients with other neurological disorders should stimulate further investigation.
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averaged many times (up to 100 times) a peak of activity could sometimes be observed to correspond with the minimum or the maximum intensity of light, according to the cell type ("off cells" or "on cells," respectively). The shape of the response, however, remained completely chaotic. An example of these results is shown in Fig. 1. Control experiments showed that the response of the retinal gan...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1943
ISSN: 0021-9738
DOI: 10.1172/jci101370